Replacing piperidine in solid phase peptide synthesis: effective Fmoc removal by alternative bases
نویسندگان
چکیده
Solid Phase Peptide Synthesis (SPPS) is a key technology for the production of pharmaceutical grade peptides and replacement piperidine with alternative bases piece puzzle moving toward greener technology.
منابع مشابه
Advances in Fmoc solid‐phase peptide synthesis
Today, Fmoc SPPS is the method of choice for peptide synthesis. Very-high-quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS. Many modified derivatives are commercially available as Fmoc building blocks, making synthetic access to a broad range of peptide derivatives straightforwa...
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ژورنال
عنوان ژورنال: Green Chemistry
سال: 2021
ISSN: ['1463-9262', '1463-9270']
DOI: https://doi.org/10.1039/d1gc02634h